Direct access to enantiomerically enriched α-amino phosphonic acid derivatives by organocatalytic asymmetric hydrophosphonylation of imines
D Pettersen, M Marcolini, L Bernardi… - The Journal of …, 2006 - ACS Publications
The Journal of Organic Chemistry, 2006•ACS Publications
A simple and efficient organocatalytic enantioselective hydrophosphonylation of imines to
enantiomerically enriched α-amino phosphonates is reported. By using 10 mol% of quinine
as the catalyst in the enantioselective addition of diethyl phosphite to N-Boc protected
imines, α-amino phosphonates are obtained in moderate to good yields and with up to 94%
ee.
enantiomerically enriched α-amino phosphonates is reported. By using 10 mol% of quinine
as the catalyst in the enantioselective addition of diethyl phosphite to N-Boc protected
imines, α-amino phosphonates are obtained in moderate to good yields and with up to 94%
ee.
A simple and efficient organocatalytic enantioselective hydrophosphonylation of imines to enantiomerically enriched α-amino phosphonates is reported. By using 10 mol % of quinine as the catalyst in the enantioselective addition of diethyl phosphite to N-Boc protected imines, α-amino phosphonates are obtained in moderate to good yields and with up to 94% ee.
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