In this paper, a systematic investigation of turbulence modulation by particles and its underlying physical mechanisms in decaying compressible isotropic turbulence is performed by using direct numerical simulations with the Eulerian–Lagrangian point-source approach. Particles interact with turbulence through two-way coupling and the initial turbulent Mach number is 1.2. Five simulations with different particle diameters (or initial Stokes numbers, ) attenuate turbulent kinetic energy and the rotational motion of fluid. The compressibility of the turbulence field is suppressed for all the cases, and the suppression is more significant if the Stokes number of particles is close to 1. The modifications of turbulent kinetic energy, the rotational motion and the compressibility are all related with the particle inertia and distributions, and the suppression of the compressibility is attributed to the preferential concentration and the inertia of particles.