Dissection of pathways implicated in integrin-mediated actin cytoskeleton assembly: involvement of protein kinase C, Rho GTPase, and tyrosine phosphorylation
P Defilippi, M Venturino, D Gulino, A Duperray… - Journal of Biological …, 1997 - ASBMB
A panel of antibodies to the αIIbβ3 integrin was used to promote adhesion of Chinese
hamster ovary cells transfected with the αIIbβ3 fibrinogen receptor. While some αIIbβ3
antibodies were not able to induce p125 focal adhesion kinase (p125FAK) tyrosine
phosphorylation, all the antibodies equally support cell adhesion but not spreading and
assembly of actin stress fibers. Absence of stress fibers was also obtained by plating on
antibodies directed to the hamster β1 integrin. In contrast, cells plated on matrix proteins …
hamster ovary cells transfected with the αIIbβ3 fibrinogen receptor. While some αIIbβ3
antibodies were not able to induce p125 focal adhesion kinase (p125FAK) tyrosine
phosphorylation, all the antibodies equally support cell adhesion but not spreading and
assembly of actin stress fibers. Absence of stress fibers was also obtained by plating on
antibodies directed to the hamster β1 integrin. In contrast, cells plated on matrix proteins …
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