Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer
SA Tomlins, B Laxman, SM Dhanasekaran… - Nature, 2007 - nature.com
Recently, we identified recurrent gene fusions involving the 5′ untranslated region of the
androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family
genes ERG, ETV1 or ETV4 in most prostate cancers,. Whereas TMPRSS2–ERG fusions are
predominant, fewer TMPRSS2–ETV1 cases have been identified than expected on the basis
of the frequency of high (outlier) expression of ETV1 (refs). Here we explore the mechanism
of ETV1 outlier expression in human prostate tumours and prostate cancer cell lines. We …
androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family
genes ERG, ETV1 or ETV4 in most prostate cancers,. Whereas TMPRSS2–ERG fusions are
predominant, fewer TMPRSS2–ETV1 cases have been identified than expected on the basis
of the frequency of high (outlier) expression of ETV1 (refs). Here we explore the mechanism
of ETV1 outlier expression in human prostate tumours and prostate cancer cell lines. We …
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer: Tomlins SA, Laxman B, Dhanasekaran SM, Helgeson BE …
SM Dehm - Urologic Oncology: Seminars and Original …, 2008 - Elsevier
Recently, we identified recurrent gene fusions involving the 5′ untranslated region of the
androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family
genes ERG, ETV1, or ETV4 in most prostate cancers. Whereas TMPRSS2-ERG fusions are
predominant, fewer TMPRSS2-ETV1 cases have been identified than expected on the basis
of the frequency of high (outlier) expression of ETV1 (references 3–13). Here we explore the
mechanism of ETV1 outlier expression in human prostate tumors and prostate cancer cell …
androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family
genes ERG, ETV1, or ETV4 in most prostate cancers. Whereas TMPRSS2-ERG fusions are
predominant, fewer TMPRSS2-ETV1 cases have been identified than expected on the basis
of the frequency of high (outlier) expression of ETV1 (references 3–13). Here we explore the
mechanism of ETV1 outlier expression in human prostate tumors and prostate cancer cell …
以上显示的是最相近的搜索结果。 查看全部搜索结果