Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers
Aldehyde dehydrogenase isoform 1 (ALDH1) has been proved useful for the identification of
cancer stem cells. However, our knowledge of the expression and activity of ALDH1 in
common epithelial cancers and their corresponding normal tissues is still largely absent.
Therefore, we characterized ALDH1 expression in 24 types of normal tissues and a large
collection of epithelial tumor specimens (six cancer types, n= 792) by immunohistochemical
staining. Using the ALDEFUOR assay, ALDH1 activity was also examined in 16 primary …
cancer stem cells. However, our knowledge of the expression and activity of ALDH1 in
common epithelial cancers and their corresponding normal tissues is still largely absent.
Therefore, we characterized ALDH1 expression in 24 types of normal tissues and a large
collection of epithelial tumor specimens (six cancer types, n= 792) by immunohistochemical
staining. Using the ALDEFUOR assay, ALDH1 activity was also examined in 16 primary …
[PDF][PDF] Distinct Expression Levels and Patterns of Stem Cell Marker
S Deng, X Yang, H Lassus… - Aldehyde …, 2010 - pdfs.semanticscholar.org
Abstract Aldehyde dehydrogenase isoform 1 (ALDH1) has been proved useful for the
identification of cancer stem cells. However, our knowledge of the expression and activity of
ALDH1 in common epithelial cancers and their corresponding normal tissues is still largely
absent. Therefore, we characterized ALDH1 expression in 24 types of normal tissues and a
large collection of epithelial tumor specimens (six cancer types, n= 792) by
immunohistochemical staining. Using the ALDEFUOR assay, ALDH1 activity was also …
identification of cancer stem cells. However, our knowledge of the expression and activity of
ALDH1 in common epithelial cancers and their corresponding normal tissues is still largely
absent. Therefore, we characterized ALDH1 expression in 24 types of normal tissues and a
large collection of epithelial tumor specimens (six cancer types, n= 792) by
immunohistochemical staining. Using the ALDEFUOR assay, ALDH1 activity was also …
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