IL-17 is the founding member of a novel family of proinflammatory cytokines that defines a
new class of CD4+ effector T cells, termed “Th17.” Mounting evidence suggests that IL-17
and Th17 cells cause pathology in autoimmunity, but little is known about mechanisms of IL-
17RA signaling. IL-17 through its receptor (IL-17RA) activates genes typical of innate
immune cytokines, such as TNFα and IL-1β, despite minimal sequence similarity in their
respective receptors. A previous bioinformatics study predicted a subdomain in IL-17-family …

138 Distinct Functional Motifs Within the IL-17 Receptor Regulate Signal Transduction and
Target Gene Expression … 138 Distinct Functional Motifs Within the IL-17 Receptor
Regulate Signal Transduction and Target Gene Expression …