Cellular membrane disruption induced by β-amyloid (Aβ) peptides has been considered one
of the major pathological mechanisms for Alzheimer disease. Mechanistic studies of the
membrane disruption process at a high-resolution level, on the other hand, are hindered by
the co-existence of multiple possible pathways, even in simplified model systems such as
the phospholipid liposome. Therefore, separation of these pathways is crucial to achieve an
in-depth understanding of the Aβ-induced membrane disruption process. This study, which …