Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus
Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection
in young children globally, but little is known about within-host RSV diversity. Here, we
characterised within-host RSV populations using deep-sequencing data from 319
nasopharyngeal swabs collected during 2017–2020. RSV-B had lower consensus diversity
than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B
consensus sequences had an amino acid alteration (K68N) in the fusion (F) protein, which …
in young children globally, but little is known about within-host RSV diversity. Here, we
characterised within-host RSV populations using deep-sequencing data from 319
nasopharyngeal swabs collected during 2017–2020. RSV-B had lower consensus diversity
than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B
consensus sequences had an amino acid alteration (K68N) in the fusion (F) protein, which …
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