(22) Filed: Sep. 8, 2008 reference Raman data set has an associated known renal sample
and an associated known renal disease state. A test (65) Prior Publication Data renal
sample is irradiated with Substantially monochromatic light to generate scattered photons
resulting in a test Raman US 2009/OOO27O2A1 Jan. 1, 2009 data set. The test Raman data
set is compared to the plurality of reference Raman data sets using a chemometric
technique. Related US Application Data Based on the comparison, a diagnosis of a renal …

Raman molecular imaging was evaluated as a tool for differentiating between kidney tumors
which are sometimes confused using conventional histopathological methods. Renal
oncocytoma and chromophobe renal cell carcinoma are two kidney tumors which
occasionally possess overlapping histological features. There is no reliable alternative
method to routine histologic examination for differentiating these neoplasms. However, a
conclusive diagnosis is important, as renal oncocytoma is benign and chromophobe renal …