From the root extracts of Salvia hypargeia, in addition to the known diter-penoids cryptanol and horminone, six new abietane diterpenoids were isolated. The structures of the new and theknown compounds were established by spectral data. The new compounds, hypargenins A, B, C, D, and F, showed antibacterial activity, while hypargenin F was also ac-tive against Mycobacterium tuberculosis. Hypargenin E did not exhibit antibacterial activity.

In a continuation of our investigations of the diterpenoid compounds of the genus Salvia (1—3), we have now studied the roots of an endemic species Salvia hypargeia Fisch. et Mey.(Labiatae). Eight abietane diterpenoids have been isolated from this plant. Two of the compounds, cryptanol (11, 12, l4-trihydroxyabieta-6, 8, 11, 13-tetraene)(1—3) and horminone (7, 12-dihydroxyabieta-8, 12-diene-l 1, 14-dione)(4), were previously known diterpenoids. The other six were new compounds: hypargenin A (6ß, 12-dihydroxyabieta-8, 11, 13-triene-1, 7-dione)[1], hypargenin B (12, 15-dihydroxyabieta-8, 11, 13-trien-7-one){2], hypargenin C (12-hydroxyabieta-8, 11, 13-triene-6, 7-dione)[3], hypargenin D (12-hydroxyabieta-6, 8, 11, 13-tetraen-3-one)[4], hypargenin E (6ß, l4-dihydroxyabieta-8, 11, 13-trien-1-one)[5], and hypargenin F (5, 12-dihy-droxyabieta-6, 8, 12-triene-11, 14-dione)[6].