Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity
Four new diterpene-type compounds normiltirone (3) and isosalviamides FH (14–16)
together with twelve known compounds (1, 2, 4–13) were isolated from the roots of Salvia
miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All
isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced
nitric oxide production in RAW264. 7 macrophages. Compound 11 showed a strong
inhibitory effect, with an IC50 value of 3.4±1.2 μM.
together with twelve known compounds (1, 2, 4–13) were isolated from the roots of Salvia
miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All
isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced
nitric oxide production in RAW264. 7 macrophages. Compound 11 showed a strong
inhibitory effect, with an IC50 value of 3.4±1.2 μM.
Abstract
Four new diterpene-type compounds normiltirone (3) and isosalviamides F-H (14–16) together with twelve known compounds (1, 2, 4–13) were isolated from the roots of Salvia miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages. Compound 11 showed a strong inhibitory effect, with an IC50 value of 3.4 ± 1.2 μM.
Taylor & Francis Online以上显示的是最相近的搜索结果。 查看全部搜索结果