Does pregnenolone adjunct to risperidone ameliorate irritable behavior in adolescents with autism spectrum disorder: a randomized, double-blind, placebo-controlled …
A Ayatollahi, S Bagheri, A Ashraf-Ganjouei… - Clinical …, 2020 - journals.lww.com
Objectives Pregnenolone is a neurosteroid with modulatory effects on γ-aminobutyric acid
neurotransmission. Here, we aimed to evaluate the effectiveness and safety of
pregnenolone add-on to risperidone in adolescents with autism spectrum disorders (ASD).
Methods Sixty-four ASD patients were randomly allocated to receive either pregnenolone
(n= 32) or matching placebo (n= 32) in addition to risperidone. The Aberrant Behavior
Checklist-Community Edition scale was used to evaluate the behavioral status of patients at …
neurotransmission. Here, we aimed to evaluate the effectiveness and safety of
pregnenolone add-on to risperidone in adolescents with autism spectrum disorders (ASD).
Methods Sixty-four ASD patients were randomly allocated to receive either pregnenolone
(n= 32) or matching placebo (n= 32) in addition to risperidone. The Aberrant Behavior
Checklist-Community Edition scale was used to evaluate the behavioral status of patients at …
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