Dose-dependent ameliorating effect of lipoxin A4 on gentamicin-induced nephrotoxicity in rats: The role of TNFα, TGF-β, ICAM-1, and JNK signaling
Gentamicin (GEN) possesses a broad range of antimicrobial effects. However, it belongs to
the aminoglycosides, and has the greatest potential for nephrotoxic effect above all other
antibiotics from this group. This study aims to evaluate the possible protective effect of
lipoxin A4 (LXA4) against GEN-induced nephrotoxicity in rats. Nephrotoxicity was induced in
male Wistar rats by injection of GEN (80 mg/kg/day, ip) for 6 days starting from day 7 of the
experiment. Rats were treated with either LXA4 (10 μg/kg/day, ip) or LXA4 (50 μg/kg/day, ip) …
the aminoglycosides, and has the greatest potential for nephrotoxic effect above all other
antibiotics from this group. This study aims to evaluate the possible protective effect of
lipoxin A4 (LXA4) against GEN-induced nephrotoxicity in rats. Nephrotoxicity was induced in
male Wistar rats by injection of GEN (80 mg/kg/day, ip) for 6 days starting from day 7 of the
experiment. Rats were treated with either LXA4 (10 μg/kg/day, ip) or LXA4 (50 μg/kg/day, ip) …
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