Dosing regimen of enrofloxacin impacts intestinal pharmacokinetics and the fecal microbiota in steers

KM Ferguson, ME Jacob, CM Theriot… - Frontiers in …, 2018 - frontiersin.org
… In conclusion, enrofloxacin penetrates the ileum and colon of cattle at high concentrations
with either the single or multiple dosing regimens causing a significant reduction in fecal E. …

The impact of therapeutic-dose induced intestinal enrofloxacin concentrations in healthy pigs on fecal Escherichia coli populations

J De Smet, F Boyen, S Croubels, G Rasschaert… - BMC veterinary …, 2020 - Springer
… considering the pig as a model for human pharmacokinetics [16], since in human healthcare
… It is the only bacterium of the fecal microbiota that was assessed in this study. However, in …

Effect of administration route and dose escalation on plasma and intestinal concentrations of enrofloxacin and ciprofloxacin in broiler chickens

M Devreese, G Antonissen, S De Baere… - BMC veterinary …, 2014 - Springer
… The ratio of enrofloxacin concentration in intestinal content/… with effects on resistance selection
in the intestinal microbiota… plasma pharmacokinetic characteristics, called pharmacokinetic

Effects of danofloxacin dosing regimen on gastrointestinal pharmacokinetics and fecal microbiome in steers

JL Halleran, BJ Callahan, ME Jacob, HJ Sylvester… - Scientific Reports, 2021 - nature.com
intestinal permeability was high for both dosing groups, and higher than what we observed
for the intestinal pharmacokinetics of enrofloxacinintestinal fluids compared to enrofloxacin

Comparisons of plasma and fecal pharmacokinetics of danofloxacin and enrofloxacin in healthy and Mannheimia haemolytica infected calves

AF Beyi, JP Mochel, G Magnin, T Hawbecker… - Scientific reports, 2022 - nature.com
… and effects on gut microbiota necessitate evaluating their … of gut microbiota to different
FQs and compared the … danofloxacin and enrofloxacin expose fecal microbiota to high …

Pharmacokinetic/pharmacodynamic assessment of the effects of parenteral administration of a fluoroquinolone on the intestinal microbiota: comparison of bactericidal …

AA Ferran, D Bibbal, T Pellet, M Laurentie… - International journal of …, 2013 - Elsevier
intestine level were investigated to predict the impact of parenteral marbofloxacin administration
on the bacteria located in the digestive … pigs only 47% of enrofloxacin was active (free …

Pharmacokinetics of enrofloxacin and ceftiofur in plasma, interstitial fluid, and gastrointestinal tract of calves after subcutaneous injection, and bactericidal impacts on …

DM Foster, ME Jacob, CD Warren… - Journal of Veterinary …, 2016 - Wiley Online Library
regimens, peak concentrations, and half-lives. Without additional study, we cannot speculate
… the effect of other ceftiofur formulations or dosage regimens on these pharmacokinetics or …

Enrofloxacin alters fecal microbiota and resistome irrespective of its dose in calves

AF Beyi, D Brito-Goulart, T Hawbecker, B Ruddell… - Microorganisms, 2021 - mdpi.com
effects of high and low doses of a single subcutaneously injected enrofloxacin on gut microbiota
pharmacokinetics and pharmacodynamics of enrofloxacin and ciprofloxacin. Second, …

The effects of different enrofloxacin dosages on clinical efficacy and resistance development in chickens experimentally infected with Salmonella Typhimurium

J Li, H Hao, G Cheng, X Wang, S Ahmed… - Scientific reports, 2017 - nature.com
pharmacokinetics study, the C max of intestinal enrofloxacin … to the antimicrobial effect of
enrofloxacin, so the effect of … been shown to alter the pharmacokinetics of drugs, including …

Studying the effect of administration route and treatment dose on the selection of enrofloxacin resistance in commensal Escherichia coli in broilers

I Chantziaras, A Smet, F Haesebrouck… - Journal of …, 2017 - academic.oup.com
… the pharmacokinetics of enrofloxacin and not on its effect on resistance selection. If the effect
… of the present study, the gut concentrations of enrofloxacin were much higher than the MPC …