Doxorubicin-loaded PLGA nanoparticles for cancer therapy: molecular weight effect of PLGA in doxorubicin release for controlling immunogenic cell death
Direct local delivery of immunogenic cell death (ICD) inducers to a tumor site is an attractive
approach for leading ICD effectively, due to enabling the concentrated delivery of ICD
inducers to the tumor site. Herein, we prepared doxorubicin (DOX)-loaded poly (lactic-co-
glycolic acid)(PLGA) nanoparticles (NPs) using different molecular weight PLGA (7000
g/mol and 12,000 g/mol), showing different drug release kinetics. The different release
kinetics of DOX might differently stimulate a tumor cell-specific immune response by …
approach for leading ICD effectively, due to enabling the concentrated delivery of ICD
inducers to the tumor site. Herein, we prepared doxorubicin (DOX)-loaded poly (lactic-co-
glycolic acid)(PLGA) nanoparticles (NPs) using different molecular weight PLGA (7000
g/mol and 12,000 g/mol), showing different drug release kinetics. The different release
kinetics of DOX might differently stimulate a tumor cell-specific immune response by …
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