Dual BACE1 and Cholinesterase Inhibitory Effects of Phlorotannins from Ecklonia cava—An In Vitro and in Silico Study
J Lee, M Jun - Marine Drugs, 2019 - mdpi.com
Alzheimer′ s disease (AD) is one of the most common neurodegenerative diseases with a
multifactorial nature. β-Secretase (BACE1) and acetylcholinesterase (AChE), which are
required for the production of neurotoxic β-amyloid (Aβ) and the promotion of Aβ fibril
formation, respectively, are considered as prime therapeutic targets for AD. In our efforts
towards the development of potent multi-target, directed agents for AD treatment, major
phlorotannins such as eckol, dieckol, and 8, 8′-bieckol from Ecklonia cava (E. cava) were …
multifactorial nature. β-Secretase (BACE1) and acetylcholinesterase (AChE), which are
required for the production of neurotoxic β-amyloid (Aβ) and the promotion of Aβ fibril
formation, respectively, are considered as prime therapeutic targets for AD. In our efforts
towards the development of potent multi-target, directed agents for AD treatment, major
phlorotannins such as eckol, dieckol, and 8, 8′-bieckol from Ecklonia cava (E. cava) were …
Dual BACE1 and cholinesterase inhibitory effects of phlorotannins from Ecklonia cava - an in vitro and in silico study.
LJH Lee JinHyuk, JMR Jun MiRa - 2019 - cabidigitallibrary.org
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases with a
multifactorial nature. β-Secretase (BACE1) and acetylcholinesterase (AChE), which are
required for the production of neurotoxic β-amyloid (Aβ) and the promotion of Aβ fibril
formation, respectively, are considered as prime therapeutic targets for AD. In our efforts
towards the development of potent multi-target, directed agents for AD treatment, major
phlorotannins such as eckol, dieckol, and 8, 8′-bieckol from Ecklonia cava (E. cava) were …
multifactorial nature. β-Secretase (BACE1) and acetylcholinesterase (AChE), which are
required for the production of neurotoxic β-amyloid (Aβ) and the promotion of Aβ fibril
formation, respectively, are considered as prime therapeutic targets for AD. In our efforts
towards the development of potent multi-target, directed agents for AD treatment, major
phlorotannins such as eckol, dieckol, and 8, 8′-bieckol from Ecklonia cava (E. cava) were …
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