The low‐grade inflammatory state present in obesity contributes to obesity‐related metabolic
dysregulation, including nonalcoholic steatohepatitis (NASH) and insulin resistance.
Intercellular interactions between immune cells or between immune cells and hepatic
parenchymal cells contribute to the exacerbation of liver inflammation and steatosis in
obesity. The costimulatory molecules, B7. 1 and B7. 2, are important regulators of cell‐cell
interactions in several immune processes; however, the role of B7 costimulation in obesity …

The inflammatory state present in obesity contributes to obesity-related metabolic
dysregulation, including non-alcoholic steatohepatitis (NASH) and insulin resistance.
Intercellular interactions between immune cells or between immune cells and hepatic
parenchymal cells contribute to the exacerbation of liver inflammation and steatosis in
obesity. The co-stimulatory molecules B7. 1 and B7. 2 are important regulators of cell-cell
interactions in several immune processes; however, the role of B7 co-stimulation in obesity …