Dynamic Ca2+ sensitivity stimulates the evolved SARS-CoV-2 spike strain-mediated membrane fusion for enhanced entry
Mutations in the spike protein generated a highly infectious and transmissible D614G
variant, which is present in newly evolved fast-spreading variants. The D614G, Alpha, Beta,
and Delta spike variants of SARS-CoV-2 appear to expedite membrane fusion process for
entry, but the mechanism of spike-mediated fusion is unknown. Here, we reconstituted an in
vitro pseudovirus-liposome fusion reaction and report that SARS-CoV-2 wild-type spike is a
dynamic Ca 2+ sensor, and D614G mutation enhances dynamic calcium sensitivity of spike …
variant, which is present in newly evolved fast-spreading variants. The D614G, Alpha, Beta,
and Delta spike variants of SARS-CoV-2 appear to expedite membrane fusion process for
entry, but the mechanism of spike-mediated fusion is unknown. Here, we reconstituted an in
vitro pseudovirus-liposome fusion reaction and report that SARS-CoV-2 wild-type spike is a
dynamic Ca 2+ sensor, and D614G mutation enhances dynamic calcium sensitivity of spike …
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