Children with frequent respiratory symptoms in infancy have an increased risk for later
wheezing, but the association with symptom dynamics is unknown. We developed an
observer-independent method to characterise symptom dynamics and tested their
association with subsequent respiratory morbidity. In this birth-cohort of healthy neonates,
we prospectively assessed weekly respiratory symptoms during infancy, resulting in a time
series of 52 symptom scores. For each infant, we calculated the transition probability …