Dynamins and BAR Proteins− Safeguards against Cancer

AC Sundborger, JE Hinshaw - Critical Reviews™ in …, 2015 - dl.begellhouse.com
Critical Reviews™ in Oncogenesis, 2015dl.begellhouse.com
Dynamins and BAR proteins are crucial in a wide variety of cellular processes for their ability
to mediate membrane remodeling, such as membrane curvature and membrane fission and
fusion. In this review, we highlight dynamins and BAR proteins and the cellular mechanisms
that are involved in the initiation and progression of cancer. We specifically discuss the roles
of the seproteinsin endocytosis, endo-lysosomal trafficking, autophagy, and apoptosis as
these processes are all tightly linked to membrane remodeling and cancer.
Abstract
Dynamins and BAR proteins are crucial in a wide variety of cellular processes for their ability to mediate membrane remodeling, such as membrane curvature and membrane fission and fusion. In this review, we highlight dynamins and BAR proteins and the cellular mechanisms that are involved in the initiation and progression of cancer. We specifically discuss the roles of the seproteinsin endocytosis, endo-lysosomal trafficking, autophagy, and apoptosis as these processes are all tightly linked to membrane remodeling and cancer.
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