Despite decades of study, elucidation of the underlying etiology of complex developmental
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual
disability (ID), and bipolar disorder (BPD) has been hampered by the inability to study
human neurons, the heterogeneity of these disorders, and the relevance of animal model
systems. Moreover, a majority of these developmental disorders have multifactorial or
idiopathic (unknown) causes making them difficult to model using traditional methods of …