[HTML][HTML] EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count
S Paolucci, I Cassaniti, F Novazzi, L Fiorina… - International Journal of …, 2021 - Elsevier
International Journal of Infectious Diseases, 2021•Elsevier
Objectives The immunologic profile and opportunistic viral DNA increase were monitored in
Italian patients with COVID-19 in order to identify markers of disease severity. Methods A
total of 104 patients infected with SARS-CoV-2 were evaluated in the study. Of them, 42/104
(40.4%) were hospitalized in an intensive care unit (ICU) and 62/104 (59.6%) in a sub-
intensive care unit (SICU). Human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV),
Parvovirus B19 and Human Herpesvirus 6 virus reactivations were determined by real-time …
Italian patients with COVID-19 in order to identify markers of disease severity. Methods A
total of 104 patients infected with SARS-CoV-2 were evaluated in the study. Of them, 42/104
(40.4%) were hospitalized in an intensive care unit (ICU) and 62/104 (59.6%) in a sub-
intensive care unit (SICU). Human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV),
Parvovirus B19 and Human Herpesvirus 6 virus reactivations were determined by real-time …
Objectives
The immunologic profile and opportunistic viral DNA increase were monitored in Italian patients with COVID-19 in order to identify markers of disease severity.
Methods
A total of 104 patients infected with SARS-CoV-2 were evaluated in the study. Of them, 42/104 (40.4%) were hospitalized in an intensive care unit (ICU) and 62/104(59.6%) in a sub-intensive care unit (SICU). Human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), Parvovirus B19 and Human Herpesvirus 6 virus reactivations were determined by real-time PCR, and lymphocyte subpopulation counts were determined by flow cytometry.
Results
Among opportunistic viruses, only EBV was consistently detected. EBV DNA was observed in 40/42 (95.2%) of the ICU patients and in 51/61 (83.6%) of the SICU patients. Comparing the two groups of patients, the EBV DNA median level among ICU patients was significantly higher than that observed in SICU patients. In parallel, a significant reduction of CD8 T cell and NK count in ICU patients as compared with SICU patients was observed (p < 0.05). In contrast, B cell count was significantly increased in ICU patients (p = 0.0172).
Conclusions
A correlation between reduced CD8+ T cells and NK counts, EBV DNA levels and COVID-19 severity was observed. Other opportunistic viral infections were not observed. The relationship between EBV load and COVID-19 severity should be further evaluated in longitudinal studies.
Elsevier
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