Background There is debate about combining benzodiazepines with selective serotonin
reuptake inhibitors in the acute treatment of panic disorder. Although this medication
combination is widely used in clinical practice, there is no well-tested, optimal method of
coadministering these medications for the treatment of panic disorder. The purpose of this
study was to test the efficacy of early coadministration of clonazepam with sertraline in the
treatment of panic disorder. Methods Fifty patients with panic disorder were randomized into …