[HTML][HTML] Early decision: meiotic crossover interference prior to stable strand exchange and synapsis
DK Bishop, D Zickler - Cell, 2004 - cell.com
DK Bishop, D Zickler
Cell, 2004•cell.comDuring meiosis, DNA double-strand breaks ultimately yield two types of recombinants:
crossovers (CO) and noncrossovers (NCO). Recent studies in budding yeast show the
CO/NCO designation occurs before stable strand exchange and thus well before Holliday
junction resolution. Chromosome synapsis occurs after CO/NCO designation and is not
required for the regulated distribution of COs along chromosomes manifested as CO
interference.
crossovers (CO) and noncrossovers (NCO). Recent studies in budding yeast show the
CO/NCO designation occurs before stable strand exchange and thus well before Holliday
junction resolution. Chromosome synapsis occurs after CO/NCO designation and is not
required for the regulated distribution of COs along chromosomes manifested as CO
interference.
Abstract
During meiosis, DNA double-strand breaks ultimately yield two types of recombinants: crossovers (CO) and noncrossovers (NCO). Recent studies in budding yeast show the CO/NCO designation occurs before stable strand exchange and thus well before Holliday junction resolution. Chromosome synapsis occurs after CO/NCO designation and is not required for the regulated distribution of COs along chromosomes manifested as CO interference.
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