Early dynamics of glial fibrillary acidic protein and extracellular DNA in plasma of mice after closed head traumatic brain injury
Background Glial fibrillary acidic protein (GFAP) in plasma is an established biomarker of
traumatic brain injury (TBI) in humans. Plasma extracellular DNA (ecDNA) is a very
sensitive, although nonspecific marker of tissue damage including TBI. Whether plasma
GFAP or ecDNA could be used as an early non-invasive biomarker in the mouse model of
closed head injury is unknown. The aim of this paper was to describe the early dynamics of
plasma GFAP and ecDNA in the animal model of closed head TBI. Methods Closed head …
traumatic brain injury (TBI) in humans. Plasma extracellular DNA (ecDNA) is a very
sensitive, although nonspecific marker of tissue damage including TBI. Whether plasma
GFAP or ecDNA could be used as an early non-invasive biomarker in the mouse model of
closed head injury is unknown. The aim of this paper was to describe the early dynamics of
plasma GFAP and ecDNA in the animal model of closed head TBI. Methods Closed head …
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