Early proteinuria lowering by angiotensin-converting enzyme inhibition predicts renal survival in children with CKD
SM van den Belt, HJL Heerspink… - Journal of the …, 2018 - journals.lww.com
Background Although pharmacotherapeutic proteinuria lowering was found to be
nephroprotective in adults, the predictive value of early drug-induced proteinuria reduction
for long-term renal survival in pediatric CKD is unknown. We analyzed data from the
ESCAPE Trial for a potential association between initial antiproteinuric effect of standardized
angiotensin-converting enzyme (ACE) inhibition and renal disease progression in children
with CKD. Methods In total, 280 eligible children with CKD stages 2–4 (mean age 11.7 years …
nephroprotective in adults, the predictive value of early drug-induced proteinuria reduction
for long-term renal survival in pediatric CKD is unknown. We analyzed data from the
ESCAPE Trial for a potential association between initial antiproteinuric effect of standardized
angiotensin-converting enzyme (ACE) inhibition and renal disease progression in children
with CKD. Methods In total, 280 eligible children with CKD stages 2–4 (mean age 11.7 years …