Early utilization of extracorporeal CO2 removal for treatment of acute respiratory distress syndrome due to smoke inhalation and burns in sheep
S Kreyer, V Scaravilli, K Linden, SM Belenkiy… - Shock, 2016 - journals.lww.com
Shock, 2016•journals.lww.com
Results: Early application of ECCO 2 R therapy with Hemolung in spontaneously breathing
sheep decreased PaCO 2 significantly, while the device removed about 70 mL of CO 2 per
minute. This did not result in lower minute ventilation in the Hemolung group. Lungpathology
and CT scans did not show a difference between groups. Conclusion: In an ovine model of
ARDS due to smoke inhalation and burn injury, early institution of ECCO 2 R in
spontaneously breathing animals was effective in removing CO 2 and in reducing PaCO 2 …
sheep decreased PaCO 2 significantly, while the device removed about 70 mL of CO 2 per
minute. This did not result in lower minute ventilation in the Hemolung group. Lungpathology
and CT scans did not show a difference between groups. Conclusion: In an ovine model of
ARDS due to smoke inhalation and burn injury, early institution of ECCO 2 R in
spontaneously breathing animals was effective in removing CO 2 and in reducing PaCO 2 …
Results:
Early application of ECCO 2 R therapy with Hemolung in spontaneously breathing sheep decreased PaCO 2 significantly, while the device removed about 70 mL of CO 2 per minute. This did not result in lower minute ventilation in the Hemolung group. Lungpathology and CT scans did not show a difference between groups.
Conclusion:
In an ovine model of ARDS due to smoke inhalation and burn injury, early institution of ECCO 2 R in spontaneously breathing animals was effective in removing CO 2 and in reducing PaCO 2. However, it had no effect on reducing the severity of lung injury or mortality. Further studies are necessary to detail the interaction between extracorporeal CO 2 removal and pulmonary physiology.
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