Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis
Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic
outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in
EBOV transcription initiation at the nucleoprotein (eNP) gene, with additional roles in the
replication cycle such as viral assembly. However, the mechanistic basis for how eVP30
functions during the virus replication cycle is currently unclear. Here we define a key
interaction between eVP30 and a peptide derived from eNP that is important to facilitate …
outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in
EBOV transcription initiation at the nucleoprotein (eNP) gene, with additional roles in the
replication cycle such as viral assembly. However, the mechanistic basis for how eVP30
functions during the virus replication cycle is currently unclear. Here we define a key
interaction between eVP30 and a peptide derived from eNP that is important to facilitate …
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