[HTML][HTML] Echovirus 1 interaction with the human very late antigen-2 (integrin α2β1) I domain: identification of two independent virus contact sites distinct from the metal …
SL King, T Kamata, JA Cunningham, J Emsley… - Journal of Biological …, 1997 - ASBMB
The human integrin very late antigen (VLA)-2 (CD49b/CD29) mediates interactions with
collagen and is the receptor for echovirus 1. Binding sites for both collagen and echovirus 1
have been mapped to the I domain within the α2 subunit of the VLA-2 α2β1 heterodimer.
Although murine VLA-2 interacts with collagen, it does not bind virus. We have used isolated
human-murine chimeric I domains expressed as glutathione S-transferase fusion proteins in
Escherichia coli to identify two groups of amino acids, 199–201 and 212–216 …
collagen and is the receptor for echovirus 1. Binding sites for both collagen and echovirus 1
have been mapped to the I domain within the α2 subunit of the VLA-2 α2β1 heterodimer.
Although murine VLA-2 interacts with collagen, it does not bind virus. We have used isolated
human-murine chimeric I domains expressed as glutathione S-transferase fusion proteins in
Escherichia coli to identify two groups of amino acids, 199–201 and 212–216 …
以上显示的是最相近的搜索结果。 查看全部搜索结果