Ficus deltoidea is believed to have a reputation for reducing the risk of diabetes and heart diseases. Diabetes mellitus has been known for many decades to be often associated with heart attack, infertility and sexual dysfunction in men. Therefore, the current study was designed to evaluate the antithrombotic activity of aqueous and ethanolic extract of Ficus deltoidea leaves and to investigate their effects have on the sperm quality and testosterone level of diabetic rats. The study was performed in five different groups for a period of four week. Two groups of diabetic rats were orally administered by aqueous and ethanolic extract of Ficus deltoidea leaves. The injection of alloxan monohydrate significantly decreased the testosterone level, sperm count and motility but significantly increased the blood glucose levels, blood clotting rate and sperm abnormalities. However, rats given aqueous and ethanolic extract of Ficus deltoidea leaves had significant improved the testosterone level, sperm count and motility. These treatments also significantly reduced the blood clotting rate, blood glucose levels and sperm abnormalities. In conclusion, effects of alloxan monohydrate induced on the blood clotting, sperm quality and testosterone level in male rats might be reversed by oral administration of the aqueous and ethanolic extract of Ficus deltoidea leaves.