This study was designed to investigate the effect of amlodipine on reproductive function in female Wistar rats. Sixteen female rats (120–160 g) were used for the estrous cycle and histopathological studies. Amlodipine (0.7 mg/kg) was administered orally on daily basis for 21 and 50 days respectively for the estrous cycle and histological studies. Estrous cycle was carried out using the technique of Marcondes et al., histologies of the ovaries and uteri were also carried out. Data were analysed using descriptive statistics and student’s t-test at p= 0.05. Treatment of rats for 21 days with amlodipine (0.7 mg/kg) produced a significant (p< 0.05) decrease in the diestrous phase with no significant (p> 0.05) changes in the proestrous, estrous and metestrous phases of the estrous cycle relative to their respective controls, as well as induced no pathological effects on the ovarian and uterine tissues in the rats. It can therefore be concluded that amlodipine probably have pro-fertility effect without deleterious effect at histological level in female Wistar rats.