Effect of beta-adrenergic blockade on plasma atrial natriuretic factor and cardiac volumes during exercise in normal men
JE Donckier, PM De Coster, M Buysschaert… - The American journal of …, 1989 - Elsevier
JE Donckier, PM De Coster, M Buysschaert, M Van Hoof, FM Cauwe, A Robert…
The American journal of cardiology, 1989•ElsevierExercise stimulates the release of the atrial natriuretic factor (ANF). 1–3 The principal
determinant of ANF release is atrial distension, 4 although adrenergic stimulation has also
been implicated in the direct release of ANF. 5, 6 Both of these mechanisms could account
for the release of ANF during exercise. To elucidate the relative roles of these mechanisms,
we determined the plasma ANF concentrations and cardiac volumes during exercise before
and after β-adrenergic blockade with propranolol.
determinant of ANF release is atrial distension, 4 although adrenergic stimulation has also
been implicated in the direct release of ANF. 5, 6 Both of these mechanisms could account
for the release of ANF during exercise. To elucidate the relative roles of these mechanisms,
we determined the plasma ANF concentrations and cardiac volumes during exercise before
and after β-adrenergic blockade with propranolol.
Abstract
Exercise stimulates the release of the atrial natriuretic factor (ANF).1–3 The principal determinant of ANF release is atrial distension,4 although adrenergic stimulation has also been implicated in the direct release of ANF.5,6 Both of these mechanisms could account for the release of ANF during exercise. To elucidate the relative roles of these mechanisms, we determined the plasma ANF concentrations and cardiac volumes during exercise before and after β-adrenergic blockade with propranolol.
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