Effect of interleukin-1 blockade on left ventricular systolic performance and work: a post hoc pooled analysis of 2 clinical trials
Background: Interleukin-1 (IL-1) blockade seems to improve anaerobic exercise in patients
with systolic heart failure through improved left ventricular (LV) systolic performance.
However, it is unclear whether IL-1 blockade affects LV systolic performance. Methods: We
pooled data from 2 clinical trials of patients with systolic heart failure who were randomized
to IL-1 blockade or placebo. We estimated changes in LV systolic performance (LV ejection
fraction [LVEF] and end-systolic elastance [LV Ees]) and pressure–volume area (PVA), a …
with systolic heart failure through improved left ventricular (LV) systolic performance.
However, it is unclear whether IL-1 blockade affects LV systolic performance. Methods: We
pooled data from 2 clinical trials of patients with systolic heart failure who were randomized
to IL-1 blockade or placebo. We estimated changes in LV systolic performance (LV ejection
fraction [LVEF] and end-systolic elastance [LV Ees]) and pressure–volume area (PVA), a …
[PDF][PDF] Effect of Interleukin-1 Blockade on Left Ventricular Systolic Performance and Work: A Post-Hoc Pooled Analysis of Two Clinical Trials
MD Dinesh Kadariya, RD Hayley Billingsley… - J Cardiovasc …, 2018 - academia.edu
Abstract Background—Interleukin-1 (IL-1) blockade appears to improve anaerobic exercise
in patients with systolic heart failure through improved left ventricular systolic performance.
However, it is unclear whether IL-1 blockade affects left ventricular systolic performance.
Methods—We pooled data from two clinical trials of patients with systolic heart failure who
were randomized to IL-1 blockade or placebo. We estimated changes in left ventricular
systolic performance (left ventricular ejection fraction [LVEF] and end-systolic elastance …
in patients with systolic heart failure through improved left ventricular systolic performance.
However, it is unclear whether IL-1 blockade affects left ventricular systolic performance.
Methods—We pooled data from two clinical trials of patients with systolic heart failure who
were randomized to IL-1 blockade or placebo. We estimated changes in left ventricular
systolic performance (left ventricular ejection fraction [LVEF] and end-systolic elastance …
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