Effect of physical activity on incidence and mortality in patients with gastric cancer: evidence from real-world studies
Cancer Causes & Control, 2023•Springer
Purpose Physical activity (PA) has been suggested to reduce the risk of cancer. However,
previous studies have been inconsistent regarding the relationship between PA and the risk
of developing gastric cancer (GC). The purpose of this study was to evaluate the impact of
PA on the incidence and mortality risk of GC through a meta-analysis, as well as investigate
potential dose-response relationships. Methods A systematic literature search was
conducted in 10 electronic databases and 4 registries. The combined relative risks (RRs) …
previous studies have been inconsistent regarding the relationship between PA and the risk
of developing gastric cancer (GC). The purpose of this study was to evaluate the impact of
PA on the incidence and mortality risk of GC through a meta-analysis, as well as investigate
potential dose-response relationships. Methods A systematic literature search was
conducted in 10 electronic databases and 4 registries. The combined relative risks (RRs) …
Purpose
Physical activity (PA) has been suggested to reduce the risk of cancer. However, previous studies have been inconsistent regarding the relationship between PA and the risk of developing gastric cancer (GC). The purpose of this study was to evaluate the impact of PA on the incidence and mortality risk of GC through a meta-analysis, as well as investigate potential dose-response relationships.
Methods
A systematic literature search was conducted in 10 electronic databases and 4 registries. The combined relative risks (RRs) were calculated using a random-effects model with 95% confidence interval (CIs) to assess the effect of PA on the risk of GC. Relevant subgroup analyses and sensitivity analyses were performed.
Results
The results showed that PA correlated with lower incidence of GC (RR: 0.83, 95% CI: 0.77–0.90), decreased risk of GC mortality (RR: 0.76, 95% CI: 0.66–0.89). The results of the subgroup analysis showed that PA was associated with reduced incidence of GC across gender, different regions, study designs, different sites of GC and different types of PA. A linear relationship was found for frequency of PA.
Conclusions
This meta-analysis found that PA was associated with a reduced risk of GC incidence and mortality. The correlation between PA and GC occurrence was in a dose-response relationship.
Springer
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