Effect of premedication with clonidine, midazolam, and dexmedetomidine on stress response and sedation in pediatric congenital cardiac surgeries
Background Children undergoing cardiac surgery experience a substantial stress response
mediated by the release of stress hormones and cytokines. Providing sedation and blunting
stress response by one drug in a single oral dose and excellent oral bioavailability of
clonidine prompted us to study its efficacy as premedication in pediatric patients and
compare it with both oral midazolam, a gold standard premedication in pediatric patient, and
oral dexmedetomidine, as a newer α 2 receptor agonist. Aim To compare the effect of …
mediated by the release of stress hormones and cytokines. Providing sedation and blunting
stress response by one drug in a single oral dose and excellent oral bioavailability of
clonidine prompted us to study its efficacy as premedication in pediatric patients and
compare it with both oral midazolam, a gold standard premedication in pediatric patient, and
oral dexmedetomidine, as a newer α 2 receptor agonist. Aim To compare the effect of …