Effect of uniaxial compression frequency on osteogenic cell responses in dynamic 3D cultures
The application of mechanical stimulation on bone tissue engineering constructs aims to
mimic the native dynamic nature of bone. Although many attempts have been made to
evaluate the effect of applied mechanical stimuli on osteogenic differentiation, the conditions
that govern this process have not yet been fully explored. In this study, pre-osteoblastic cells
were seeded on PLLA/PCL/PHBV (90/5/5 wt.%) polymeric blend scaffolds. The constructs
were subjected every day to cyclic uniaxial compression for 40 min at a displacement of 400 …
mimic the native dynamic nature of bone. Although many attempts have been made to
evaluate the effect of applied mechanical stimuli on osteogenic differentiation, the conditions
that govern this process have not yet been fully explored. In this study, pre-osteoblastic cells
were seeded on PLLA/PCL/PHBV (90/5/5 wt.%) polymeric blend scaffolds. The constructs
were subjected every day to cyclic uniaxial compression for 40 min at a displacement of 400 …
[PDF][PDF] Effect of Uniaxial Compression Frequency on Osteogenic Cell Responses in Dynamic 3D Cultures. Bioengineering 2023, 10, 532
The application of mechanical stimulation on bone tissue engineering constructs aims to
mimic the native dynamic nature of bone. Although many attempts have been made to
evaluate the effect of applied mechanical stimuli on osteogenic differentiation, the conditions
that govern this process have not yet been fully explored. In this study, pre-osteoblastic cells
were seeded on PLLA/PCL/PHBV (90/5/5 wt.%) polymeric blend scaffolds. The constructs
were subjected every day to cyclic uniaxial compression for 40 min at a displacement of 400 …
mimic the native dynamic nature of bone. Although many attempts have been made to
evaluate the effect of applied mechanical stimuli on osteogenic differentiation, the conditions
that govern this process have not yet been fully explored. In this study, pre-osteoblastic cells
were seeded on PLLA/PCL/PHBV (90/5/5 wt.%) polymeric blend scaffolds. The constructs
were subjected every day to cyclic uniaxial compression for 40 min at a displacement of 400 …
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