Renal replacement therapy is a treatment option for people who have acute or chronic renal failure. A patient with increasing symptoms of renal failure is referred to a dialysis and transplantation center early in the course of progressive kidney disease. Hemodialysis is one of the most widely used dialysis procedures. Muscle cramps are the most common complication experienced by hemodialysis patients that usually develop during and in between hemodialysis therapy. These cramps appear to be the most common reason for the early termination of the hemodialysis session. Pretest-posttest non-blind randomized controlled trial has been used in the present study to evaluate the effectiveness of Intradialytic stretching exercises on the leg muscle cramps among patients undergoing hemodialysis, from the period of September 5th, 2020 to March 22nd, 2021. Non-probability purposive Sample of 60 patients undergoing hemodialysis. The sample is divided randomly into two groups; 30 patients as the study group and the other 30 as the control group. The setting of the study: The study is conducted in Al-Najaf City/Al-Najaf Al-Ashraf Health Directorate/Al-Sadder Medical City/The specialized center for kidney diseases and transplantation/Hemodialysis Unit. The study result signifies that the level of muscle cramps improved significantly among the study group participants compared with control group.