Effects of 5-HT-7 receptor ligands on memory and cognition
N Zareifopoulos, C Papatheodoropoulos - Neurobiology of learning and …, 2016 - Elsevier
Neurobiology of learning and memory, 2016•Elsevier
The 5-HT7R is the most recently cloned serotonin receptor and thus one the least studied.
Many drugs, experimental and in clinical use bind to 5-HT7 with high affinity, though their
effects have yet to be clearly elucidated. Its physiological function, though not completely
clear, is mostly associated with learning and memory, with both agonists and antagonists
possessing subtle procognitive and promnesic properties. We consider it a promising area
of research, though still in its infancy, which may one day lead to clinical benefits for patients …
Many drugs, experimental and in clinical use bind to 5-HT7 with high affinity, though their
effects have yet to be clearly elucidated. Its physiological function, though not completely
clear, is mostly associated with learning and memory, with both agonists and antagonists
possessing subtle procognitive and promnesic properties. We consider it a promising area
of research, though still in its infancy, which may one day lead to clinical benefits for patients …
Abstract
The 5-HT7R is the most recently cloned serotonin receptor and thus one the least studied. Many drugs, experimental and in clinical use bind to 5-HT7 with high affinity, though their effects have yet to be clearly elucidated. Its physiological function, though not completely clear, is mostly associated with learning and memory, with both agonists and antagonists possessing subtle procognitive and promnesic properties. We consider it a promising area of research, though still in its infancy, which may one day lead to clinical benefits for patients with various afflictions characterised by cognitive dysfunction, particularily autism spectrum disorder, fragile X syndrome and Alzheimer’s disease.
Elsevier
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