[HTML][HTML] Effects of Labisia pumila on oxidative stress in rat model of post-menopausal osteoporosis
Asian Pacific Journal of Reproduction, 2016•Elsevier
Objective To analyze the effects of Labisia pumila (L. pumila) extract on the markers of
oxidative stress in ovariectomized rats. Methods Twenty-five female Wistar rats were divided
into five treatment groups (n= 5): the control group, the ovariectomized group, the
ovariectomized group treated with L. pumila extract of various doses (10 mg/kg, 20 mg/kg,
and 40 mg/kg). L. pumila extract was administered daily for 8 weeks. Results The levels of
malondialdehyde and superoxide dismutase (SOD) were subjected to spectrophotometric …
oxidative stress in ovariectomized rats. Methods Twenty-five female Wistar rats were divided
into five treatment groups (n= 5): the control group, the ovariectomized group, the
ovariectomized group treated with L. pumila extract of various doses (10 mg/kg, 20 mg/kg,
and 40 mg/kg). L. pumila extract was administered daily for 8 weeks. Results The levels of
malondialdehyde and superoxide dismutase (SOD) were subjected to spectrophotometric …
Objective
To analyze the effects of Labisia pumila (L. pumila) extract on the markers of oxidative stress in ovariectomized rats.
Methods
Twenty-five female Wistar rats were divided into five treatment groups (n = 5): the control group, the ovariectomized group, the ovariectomized group treated with L. pumila extract of various doses (10 mg/kg, 20 mg/kg, and 40 mg/kg). L. pumila extract was administered daily for 8 weeks.
Results
The levels of malondialdehyde and superoxide dismutase (SOD) were subjected to spectrophotometric analysis. Serum levels of malondialdehyde and SOD were significantly higher in the group of rat model of post-menopausal osteoporosis than that of the control group (P < 0.05). All doses of L. pumila administered significantly decreased the serum levels of malondialdehyde relative to the group of rat model of post-menopausal osteoporosis, reaching the levels comparable to those of the control group (P < 0.05). The second dose of L. pumila significantly decreased the levels of SOD relative to those of the group of rat model of post-menopausal osteoporosis, although it did not reach the levels of SOD of the control group (P < 0.05).
Conclusion
The ethanol extract of L. pumila normalizes lipid peroxidation in the rat model of post-menopausal osteoporosis via the mechanism of endogenous antioxidant replacement.
Elsevier
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