To evaluate and compare the effects on high-sensitivity C-reactive protein (hs-CRP) levels and lipid profile of atorvastatin and rosuvastatin in obese type 2 diabetes mellitus (T2DM) patients. A total of 40 subjects with 20 in each group were randomly allocated to two groups. Group 1 patients received atorvastatin and that of Group 2 rosuvastatin treatment for 6 months. The patients were administered atorvastatin (40-80 mg) and rosuvastatin (10-40 mg) in accordance to their LDL-C status as per NCEP-ATP III guidelines. The parameters studied were, hs-CRP and lipid profile comprising LDL-C, HDL-C, TG and TC. Results obtained from the study, clearly indicate that atorvastatin (A) as well as rosuvastatin (R) have significant effect on lowering of hs-CRP levels (for A P= 0.001; for R P= 0.002), reducing LDL-C levels (for A P= 0.008; for R P= 0.001), elevating HDL-C levels (for A P= 0.02; for R P= 0.001) along with reducing TC (for A P= 0.003; for R P= 0.002) and TG (for A P= 0.000; for R P= 0.000) levels in obese T2DM patients. It is also seen that there is no significant (P> 0.05) difference in effect of atorvastatin and rosuvastatin in lowering of hs-CRP levels, elevating HDL-C levels and reducing TG levels in obese T2DM patients. However, percentage lowering of LDL-C (P= 0.000) and TC (P= 0.001) by rosuvastatin is to a greater extent than that caused by atorvastatin in these patients. Thus this study throws light on the fact that rosuvastatin should be preferred over atorvastatin in obese T2DM patients in whom LDL-C and TC levels are deviated from normal reference values. In rest of obese T2DM either of atorvastatin or rosuvastatin can be employed to lower hs-CRP levels, to elevate HDL-C levels or to reduce TG levels.