Recent data indicates that kisspeptin, encoded by the KISS1 gene, could play a role in
transducing metabolic information into the hypothalamic–pituitary–gonadal (HPG) axis, the
mechanism that controls reproductive functions. Numerous studies have shown that in a
state of negative energy balance, the hypothalamic kisspeptin system is impaired. However,
data concerning positive energy balance (eg diabetes and obesity) and the role of
kisspeptin in the peripheral tissues is scant. We hypothesized that: 1) in diet-induced obese …