Effects of policosanol on platelet aggregation in rats

ML Arruzazabala, D Carbajal, R Mas, M Garcia… - Thrombosis research, 1993 - Elsevier
Policosanol is the trivial name of a mixture of high molecular weight alcohols isolated from
sugar cane, wherein octacosanol is the main component The effects of Policosanol
treatment on rat platelet aggregation were studied. Depending on the dose, Policosanol (5–
20 mg/kg, perorally) inhibited the decrease in circulating platelet counts and collagen-
induced malondialdehyde concentration in plasma. In rat clotted whole blood thromboxane
B2 formation was inhibited by Policosanol (25 mg/kg). Policosanol (50–200 mg/kg, single …
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