Effects of Saffron (Crocus sativus L.) and its Active Constituent, Crocin, on Recognition and Spatial Memory after Chronic Cerebral Hypoperfusion in Rats
H Hosseinzadeh, HR Sadeghnia… - Phytotherapy …, 2012 - Wiley Online Library
Cerebral ischemia produces brain damage and related behavioral deficits such as memory.
In this study, a rat model of chronic cerebral hypoperfusion was used to determine whether
saffron extract and crocin, which are potent antioxidants and free radical scavengers, can
reduce vascular cognitive impairment. Male adult Wistar rats were administered different
doses of an aqueous solution of crocin or hydroalcohol extract of saffron intraperitoneally
(ip) 5 days after permanent occlusion of the common carotid arteries. Spatial learning and …
In this study, a rat model of chronic cerebral hypoperfusion was used to determine whether
saffron extract and crocin, which are potent antioxidants and free radical scavengers, can
reduce vascular cognitive impairment. Male adult Wistar rats were administered different
doses of an aqueous solution of crocin or hydroalcohol extract of saffron intraperitoneally
(ip) 5 days after permanent occlusion of the common carotid arteries. Spatial learning and …
Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats
FA Ghaeni, S Mohajeri… - Research in …, 2012 - rps.mui.ac.ir
… Background and Aims: In this study, a rat model of chronic cerebral hypoperfusion was
used to determine whether saffron extract and crocin, which are potent antioxidants and free
radical scavengers, can reduce vascular cognitive impairment. Methods: Male adult Wistar rats
were administered different doses of an aqueous solution of … The percentages of time spent
in the target quadrant, in comparison with the control group (24.16%), increased to 34.25% in
the crocin (25mg/kg) and 34.85% in the saffron extract (250mg/kg) group. Conclusions: saffron …
used to determine whether saffron extract and crocin, which are potent antioxidants and free
radical scavengers, can reduce vascular cognitive impairment. Methods: Male adult Wistar rats
were administered different doses of an aqueous solution of … The percentages of time spent
in the target quadrant, in comparison with the control group (24.16%), increased to 34.25% in
the crocin (25mg/kg) and 34.85% in the saffron extract (250mg/kg) group. Conclusions: saffron …
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