In a previous report we presented a novel behavioral model of neuropathic pain disorders,
produced in rat by a unilateral ligation of about half of the sciatic nerve. The model is
characterized by rapid onset of behaviors suggesting spontaneous pain and disordered
responses to non-noxious and noxious stimuli. These include reduced withdrawal
thresholds to repetitive touch in the partially deafferented skin (“touched-evoked
hyperesthesia”), touch-evoked allodynia, reduced withdrawal thresholds to noxious thermal …