The endosomal sorting complex required for transport (ESCRT) is formed by ESCRT-0,
ESCRT-I, ESCRT-II, ESCRT-III complexes, and accessory proteins. It conducts vesicular
trafficking in eukaryotes through the formation of vesicles and membrane fission and fusion
events. The trophozoites of Entamoeba histolytica, the protozoan responsible for human
amoebiasis, presents an active membrane movement in basal state that increases during
phagocytosis and tissue invasion. ESCRT-III complex has a pivotal role during these events …

H. sapiens (TGS101) and S. cerevisiae Vps23 proteins sequences (access numbers:
Q99816 and P25604, respectively), retrieved from the Uniprot database (https://www.
uniprot. org) were used as query to search an E. histolytica Vps23 protein (EhVps23) in the
AmoebaDB database (https://amoebadb. org/amoeba/app). Structural domains of the
candidates were identified using the SMART genomics server (http://smart. embl-heidelberg.
de/) and the motif tool of KEGG (https://www. genome. jp/kegg/). The predicted amino acid …