Background The klotho gene was identified as an “aging-suppressor” gene that accelerates
arterial calcification when disrupted. Serum and vascular klotho levels are reduced in
patients with chronic kidney disease, and the reduced levels are associated with arterial
calcification. Intake of eicosapentaenoic acid (EPA), an n-3 fatty acid, reduces the risk of fatal
coronary artery disease. However, the effects of EPA on arterial calcification have not been
fully elucidated. The aim of this study was to determine the effect of EPA on arterial …

Background: Vascular calcification is frequently found in patients with coronary artery
disease, and is associated with the incidence of cardiovascular events. Several studies have
indicated that intake of n-3 (omega-3) fatty acids from fish reduces the risk of fatal coronary
artery disease. However, the effects of n-3 fatty acids on arterial calcification have not been
fully elucidated. Purpose: The aim of this study is to assess the effect of eicosapentaenoic
acid (EPA), an n-3 fatty acid, on arterial calcification in klotho mutant mice, an animal model …