Elevated Endothelial Cell, Platelet and T-Cell Microparticles in Psoriasis May Provide Novel Link to Atherosclerosis
Journal of the American College of Cardiology, 2012•jacc.org
Background Severe psoriasis is a risk factor for cardiovascular (CV) disease beyond
traditional risk factors; however, the mechanism remains unknown. Recent findings suggest
that cell membrane vesicles, or microparticles, which are released upon cell activation or
apoptosis, are associated with CV disease and may play a pathogenic role. Levels of
microparticles, particularly from endothelial cells, platelets and T-cells are elevated in
patients with cardiovascular disorders and have recently been shown to be predictive of CV …
traditional risk factors; however, the mechanism remains unknown. Recent findings suggest
that cell membrane vesicles, or microparticles, which are released upon cell activation or
apoptosis, are associated with CV disease and may play a pathogenic role. Levels of
microparticles, particularly from endothelial cells, platelets and T-cells are elevated in
patients with cardiovascular disorders and have recently been shown to be predictive of CV …
Background
Severe psoriasis is a risk factor for cardiovascular (CV) disease beyond traditional risk factors; however, the mechanism remains unknown. Recent findings suggest that cell membrane vesicles, or microparticles, which are released upon cell activation or apoptosis, are associated with CV disease and may play a pathogenic role. Levels of microparticles, particularly from endothelial cells, platelets and T-cells are elevated in patients with cardiovascular disorders and have recently been shown to be predictive of CV outcomes.
Methods
To understand if microparticles may serve as a potential link between psoriasis and CV disease, absolute circulating microparticle levels, concentrations, and types (endothelial, platelet, and T cell-derived) of microparticles were measured in blood samples from psoriasis patients (n= 20) and compared to healthy controls (n= 41). Platelet-poor plasma was separated from whole blood after high-speed centrifugation for microparticle analysis. Microparticles were fluorescently labeled and characterized by flow cytometry.
Results
We found higher absolute microparticle levels (2.6-fold increase; 721,123 vs 277,108; p< 0.01) and microparticle concentration (5-fold increase; 1,669,625 vs 333,339 particles per uL; p= 0.01) in psoriasis compared to healthy controls, which persisted after adjustment for traditional cardiovascular disease risk factors. Characterization of the microparticles revealed a predominance of endothelial-, platelet-, and T cell-derived microparticles, all of which were present in higher absolute levels in psoriasis patients compared to healthy controls (108 vs 37, p< 0.01; 70,585 vs 4,727, p< 0.01; 995 vs 161, p= 0.03, respectively) beyond traditional risk factors (p< 0.001 for all).
Conclusions
These findings of increased microparticle levels, independent of cardiovascular risk factors, in psoriasis suggests that the presence of increased endothelial cell, platelet and T-cell activation with cell turnover may contribute to the heightened atherosclerosis observed in psoriasis.
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