[HTML][HTML] Elevated high-sensitivity c-reactive protein and interleukin-6 plasma as risk factors for symptomatic lumbar osteoarthritis in postmenopausal women
IK Suyasa, AAW Lestari, IGNY Setiawan… - … Journal of Medical …, 2018 - ncbi.nlm.nih.gov
Open Access Macedonian Journal of Medical Sciences, 2018•ncbi.nlm.nih.gov
AIM: To determine whether elevated high-sensitivity C-reactive protein (hs-CRP), interleukin-
6 (IL-6), and erythrocyte sedimentation rate (ESR), as risk factors of symptomatic lumbar
osteoarthritis (OA) in estrogen deficiency postmenopausal women. METHODS: A case-
control study was conducted between January and June 2017. The inclusion criteria include
post-menopausal women with estrogen deficiency with low back pain. Exclusion criteria
were: patients with a history of undergoing bilateral oophorectomy, taking hormonal …
6 (IL-6), and erythrocyte sedimentation rate (ESR), as risk factors of symptomatic lumbar
osteoarthritis (OA) in estrogen deficiency postmenopausal women. METHODS: A case-
control study was conducted between January and June 2017. The inclusion criteria include
post-menopausal women with estrogen deficiency with low back pain. Exclusion criteria
were: patients with a history of undergoing bilateral oophorectomy, taking hormonal …
Abstract
AIM:
To determine whether elevated high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and erythrocyte sedimentation rate (ESR), as risk factors of symptomatic lumbar osteoarthritis (OA) in estrogen deficiency postmenopausal women.
METHODS:
A case-control study was conducted between January and June 2017. The inclusion criteria include post-menopausal women with estrogen deficiency with low back pain. Exclusion criteria were: patients with a history of undergoing bilateral oophorectomy, taking hormonal replacement therapy or corticosteroid, malignancies, and lumbosacral spine trauma. The blood examinations were taken to measure IL-6 level by ELISA, hs-CRP level by spectrophotometry and ESR by modified Westergren method.
RESULTS:
A group of 44 pairs of subjects were divided equally into case and control groups showed that in estrogen deficiency postmenopausal women, an increased level of hs-CRP increased the risk for symptomatic lumbar OA (OR= 2.83, CI95%= 1.065-8.776, p= 0.034). Also, a high level of IL-6 increased the risk of symptomatic lumbar OA (OR= 2.7, CI95%= 0.991-8.320, p= 0.033). No such significant findings were found for an increased ESR level.
CONCLUSION:
Elevated level of plasma hs-CRP and IL-6 were concluded as risk factors for symptomatic lumbar OA in post-menopausal women.
ncbi.nlm.nih.gov
以上显示的是最相近的搜索结果。 查看全部搜索结果