Recent epidemiologic studies suggest that uric acid predicts the development of new-onset
kidney disease, but it is unclear whether uric acid is an independent risk factor. In this study,
data from 21,475 healthy volunteers who were followed prospectively for a median of 7 yr
were analyzed to examine the association between uric acid level and incident kidney
disease (estimated GFR [eGFR]< 60 ml/min per 1.73 m 2). After adjustment for baseline
eGFR, a slightly elevated uric acid level (7.0 to 8.9 mg/dl) was associated with a nearly …