Emergence of the epidemic methicillin-resistant Staphylococcus aureus strain USA300 coincides with horizontal transfer of the arginine catabolic mobile element and …
The arginine catabolic mobile element (ACME) is the largest genomic region distinguishing
epidemic USA300 strains of methicillin-resistant Staphylococcus aureus (MRSA) from other
S. aureus strains. However, the functional relevance of ACME to infection and disease has
remained unclear. Using phylogenetic analysis, we have shown that the modular segments
of ACME were assembled into a single genetic locus in Staphylococcus epidermidis and
then horizontally transferred to the common ancestor of USA300 strains in an extremely …
epidemic USA300 strains of methicillin-resistant Staphylococcus aureus (MRSA) from other
S. aureus strains. However, the functional relevance of ACME to infection and disease has
remained unclear. Using phylogenetic analysis, we have shown that the modular segments
of ACME were assembled into a single genetic locus in Staphylococcus epidermidis and
then horizontally transferred to the common ancestor of USA300 strains in an extremely …
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